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ACE inhibitors may rarely reduce renal function, a risk factor for reduced renal clearance of metformin. interfering with the cellular capacity to secrete PSA. Zonisamide: (Moderate) Zonisamide frequently decreases serum bicarbonate and induces non-anion gap, hyperchloremic metabolic acidosis. Tags: anxiety disorder, depression, Elavil, Ginseng, Haldol, Kava Kava, lithium, lobotomy, Melatonin, Peter Breggin, Prozac, Ritalin, schizophrenia, St.